Research

 

Scientific References

Alagumuthu, M., Dahiya, D. and Singh Nigam, P. (2019). Phospholipid—the dynamic structure between living and non-living world; a much obligatory supramolecule for present and future. AIMS Molecular Science, 6(1), pp.1-19.

Suleimanova RR, Hudz EA, Melnychuk DO, Kalachniuk LH(2017) Age-related changes phospholipids of sterlet in liver and dorsal muscles. Ukr Biochem J 89:71–75.

Kim, B., Park, S. Phosphatidylserine modulates response to oxidative stress through hormesis and increases lifespan via DAF-16 in Caenorhabditis elegans. Biogerontology (2020).

Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., & Abete, P. (2018). Oxidative stress, aging, and diseases. Clinical interventions in aging, 13, 757–772.

H Van Remmen, Oxidative Stress And Age-related Diseases, Innovation In Aging, Volume 2, Issue Suppl_1, 1 November 2018, Page 347.

Michael J. Glade Ph.D., Kyl Smith D.C., Phosphatidylserine and the human brain, Nutrition 31 (2015) 781–786.

Parker AG1, Gordon J, Thornton A, Byars A, Lubker J, Bartlett M, Byrd M, Oliver J, Simbo S, Rasmussen C, Greenwood M, Kreider RB, The effects of IQ PLUS Focus on cognitive function, mood and endocrine response before and following acute exercise, J Int Soc Sports Nutr. 2011 Oct 21;8:16.

Kidd, Parris. (1996). Phosphatidylserine; Membrane Nutrient for Memory. A Clinical and Mechanistic Assessment. Altern. Med. Rev.

Caffara P, Santamaria V. The effects of phosphatidylserine in patients with mild cognitive decline. An open trial. Clin Trials J 1987;24:109–14

Schreiber S, Kampf-Sherf O, Gorfine M, Kelly D, Oppenheim Y, Lerer B. An open trial of plant-source derived phosphatidylserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302–7.

Richter Y, Herzog Y, Cohen T, Steinhart Y. The effect of phosphatidylserine containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study. Clin Interv Aging 2010;5: 313–6

Richter Y, Herzog Y, Lifshitz Y, Hayun R, Zchut S. The effect of soybean derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study. Clin Interv Aging 2013;8: 557–63

Komori T. The Effects of Phosphatidylserine and Omega-3 Fatty Acid-Containing Supplement on Late Life Depression. Ment Illn 2015;7:5647.

Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016). Associations between Sleep, Cortisol Regulation, and Diet: Possible Implications for the Risk of Alzheimer Disease. Advances in nutrition (Bethesda, Md.), 7(4), 679–689.

Benton D, Donohoe RT, Sillance B, Nabb S: The Influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci. 2001, 4 (3): 169-178.

Starks, M.A., Starks, S.L., Kingsley, M. et al. The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc Sports Nutr 5, 11 (2008).

Hellhammer, J., Vogt, D., Franz, N., Freitas, U., & Rutenberg, D. (2014). A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study. Lipids in health and disease, 13, 121. 

Hirayama S, Terasawa K, Rabeler R, Hirayama T, Inoue T, Tatsumi Y, Purpura M, Jäger R, The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial, J Hum Nutr Diet. 2014 Apr;27 Suppl 2:284-91.

Dr. Axe.Phosphatidylserine, What Is Phosphatidylserine? (Top 6 Benefits & How to Use It), September 27, 2019.

Souci SW, Fachmann E, Kraut H. (Book). Food Composition and Nutrition Tables. Medpharm Scientific Publishers Stuttgart. (2008).

Engel RR, Satzger W, Günther W, et al. Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. Eur Neuropsychopharmacol. 1992; 2(2): 149-55.

Cenacchi T, Bertoldin T, Farina C, Fiori MG, Crepaldi G. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging (Milano). 1993; 5(2): 123-33. 

Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T. Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints J. Clin. Biochem. Nutr.. 2010; 47(3): 246-255.

Hirayama S, Terasawa K, Rabeler R, et al. The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. J Hum Nutr Diet. 2014; 27 Suppl 2: 284-91

Hellhammer J, Fries E, Buss C, et al. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 2004; 7(2): 119-26.

Valadas JS, Esposito G, Vandekerkhove D, et al. ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease. Neuron. 2018; 98(6): 1155-1169.e6.

Maggioni M, Picotti GB, Bondiolotti GP, et al. Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr Scand. 1990; 81(3): 265-70.

Lise A. Treatment Considerations for Generalized Anxiety Disorder. Natural Medicine Journal. 2014; 6(4).

Kingsley MI, Miller M, Kilduff LP, McEneny J, Benton D. Effects of phosphatidylserine on exercise capacity during cycling in active males. Med Sci Sports Exerc. 2006; 38(1): 64-71.

Kingsley MI, Kilduff LP, McEneny J, Dietzig RE, Benton D. Phosphatidylserine supplementation and recovery following downhill running. Med Sci Sports Exerc. 2006; 38(9): 1617-25.

Monteleone P, Beinat L, Tanzillo C, Maj M, Kemali D. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology. 1990; 52(3): 243-8.

Monteleone P, Maj M, Beinat L, Natale M, Kemali D. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol. 1992; 42(4): 385-8

 

 

 

 

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Scientific References

Alagumuthu, M., Dahiya, D. and Singh Nigam, P. (2019). Phospholipid—the dynamic structure between living and non-living world; a much obligatory supramolecule for present and future. AIMS Molecular Science, 6(1), pp.1-19.

Suleimanova RR, Hudz EA, Melnychuk DO, Kalachniuk LH(2017) Age-related changes phospholipids of sterlet in liver and dorsal muscles. Ukr Biochem J 89:71–75.

Kim, B., Park, S. Phosphatidylserine modulates response to oxidative stress through hormesis and increases lifespan via DAF-16 in Caenorhabditis elegans. Biogerontology (2020).

Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., & Abete, P. (2018). Oxidative stress, aging, and diseases. Clinical interventions in aging, 13, 757–772.

H Van Remmen, Oxidative Stress And Age-related Diseases, Innovation In Aging, Volume 2, Issue Suppl_1, 1 November 2018, Page 347.

Michael J. Glade Ph.D., Kyl Smith D.C., Phosphatidylserine and the human brain, Nutrition 31 (2015) 781–786.

Parker AG1, Gordon J, Thornton A, Byars A, Lubker J, Bartlett M, Byrd M, Oliver J, Simbo S, Rasmussen C, Greenwood M, Kreider RB, The effects of IQ PLUS Focus on cognitive function, mood and endocrine response before and following acute exercise, J Int Soc Sports Nutr. 2011 Oct 21;8:16.

Kidd, Parris. (1996). Phosphatidylserine; Membrane Nutrient for Memory. A Clinical and Mechanistic Assessment. Altern. Med. Rev.

Caffara P, Santamaria V. The effects of phosphatidylserine in patients with mild cognitive decline. An open trial. Clin Trials J 1987;24:109–14

Schreiber S, Kampf-Sherf O, Gorfine M, Kelly D, Oppenheim Y, Lerer B. An open trial of plant-source derived phosphatidylserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302–7.

Richter Y, Herzog Y, Cohen T, Steinhart Y. The effect of phosphatidylserine containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study. Clin Interv Aging 2010;5: 313–6

Richter Y, Herzog Y, Lifshitz Y, Hayun R, Zchut S. The effect of soybean derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study. Clin Interv Aging 2013;8: 557–63

Komori T. The Effects of Phosphatidylserine and Omega-3 Fatty Acid-Containing Supplement on Late Life Depression. Ment Illn 2015;7:5647.

Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016). Associations between Sleep, Cortisol Regulation, and Diet: Possible Implications for the Risk of Alzheimer Disease. Advances in nutrition (Bethesda, Md.), 7(4), 679–689.

Benton D, Donohoe RT, Sillance B, Nabb S: The Influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci. 2001, 4 (3): 169-178.

Starks, M.A., Starks, S.L., Kingsley, M. et al. The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc Sports Nutr 5, 11 (2008).

Hellhammer, J., Vogt, D., Franz, N., Freitas, U., & Rutenberg, D. (2014). A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study. Lipids in health and disease, 13, 121.

Hirayama S, Terasawa K, Rabeler R, Hirayama T, Inoue T, Tatsumi Y, Purpura M, Jäger R, The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial, J Hum Nutr Diet. 2014 Apr;27 Suppl 2:284-91.

Hellhammer, J., Vogt, D., Franz, N., Freitas, U., & Rutenberg, D. (2014). A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study. Lipids in health and disease, 13, 121.

Dr. Axe.Phosphatidylserine, What Is Phosphatidylserine? (Top 6 Benefits & How to Use It), September 27, 2019.

Souci SW, Fachmann E, Kraut H. (Book). Food Composition and Nutrition Tables. Medpharm Scientific Publishers Stuttgart. (2008).

Engel RR, Satzger W, Günther W, et al. Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. Eur Neuropsychopharmacol. 1992; 2(2): 149-55.

Cenacchi T, Bertoldin T, Farina C, Fiori MG, Crepaldi G. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging (Milano). 1993; 5(2): 123-33.

Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T. Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints J. Clin. Biochem. Nutr.. 2010; 47(3): 246-255.

Hirayama S, Terasawa K, Rabeler R, et al. The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. J Hum Nutr Diet. 2014; 27 Suppl 2: 284-91.

Hellhammer J, Fries E, Buss C, et al. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 2004; 7(2): 119-26.

Valadas JS, Esposito G, Vandekerkhove D, et al. ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease. Neuron. 2018; 98(6): 1155-1169.e6.

Maggioni M, Picotti GB, Bondiolotti GP, et al. Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr Scand. 1990; 81(3): 265-70.

Lise A. Treatment Considerations for Generalized Anxiety Disorder. Natural Medicine Journal. 2014; 6(4).

Kingsley MI, Miller M, Kilduff LP, McEneny J, Benton D. Effects of phosphatidylserine on exercise capacity during cycling in active males. Med Sci Sports Exerc. 2006; 38(1): 64-71.

Kingsley MI, Kilduff LP, McEneny J, Dietzig RE, Benton D. Phosphatidylserine supplementation and recovery following downhill running. Med Sci Sports Exerc. 2006; 38(9): 1617-25.

Monteleone P, Beinat L, Tanzillo C, Maj M, Kemali D. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology. 1990; 52(3): 243-8.

Monteleone P, Maj M, Beinat L, Natale M, Kemali D. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol. 1992; 42(4): 385-8